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Alzheimer's Association International Conference 2026

July 12-15, 2026 | London, United Kingdom, and Online

2916

Activities Of Daily Living And Volumetric Brain Measures In Alzheimer’s Disease Spectrum.

Preview of Activities Of Daily Living And Volumetric Brain Measures In Alzheimer’s Disease Spectrum.

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Poster Presenter

Authors

Joanne M. Scotney, Louise N. Pivac, Yunwei Zhang, Belinda M. Brown, Paul Maruff, Samantha L. Gardener, Vincent Doré, Simon M. Laws, Victor L. Villemagne, Pierrick Bourgeat, Christopher C. Rowe, Stephanie R. Rainey-Smith, Kevin Taddei, Colin L. Masters, Ralph N. Martins, Hamid R. Sohrabi

Affiliations

1. Murdoch University, Centre for Healthy Ageing, Health Futures Institute, Murdoch, WA, Australia. 2. Murdoch University, School of Psychology, Murdoch, WA, Australia., 2. Murdoch University, School of Psychology, Murdoch, WA, Australia., 3. Murdoch University, School of Mathematics, Statistics, Chemistry and Physics, Murdoch, WA, Australia. 4. Macquarie University, School of Mathematical and Physical Sciences, Sydney, NSW, Australia. 5. The University of Sydney, School of Mathematics and Statistics, NSW, Australia., 1. Murdoch University, Centre for Healthy Ageing, Health Futures Institute, Murdoch, WA, Australia., 6. Cogstate Ltd, Melbourne, Victoria, Australia., 7. Alzheimer’s Research Australia, Ralph and Patricia Sarcih Neuroscience Research Institute, Nedlands, WA, Australia. 9. Edith Cowan University, School of Medical and Health Sciences, Joondalup, WA, Australia. 10. The University of Western Australia Medical School, Crawley, WA, Australia., 12. Austin Health, Department of Molecular Imaging & Therapy, Heidelberg, Victoria, Australia. 13. The Australian e-Health Research Centre, CSIRO Health and Biosecurity, Parkerville, Victoria, Australia., 15. Edith Cowan University, Centre for Precision Health, Joondalup, Australia. 16. Edith Cowan University, School of Medical and Health Sciences, Collaborative Genomics and Translational Group, Joondalup, Australia., 12. Austin Health, Department of Molecular Imaging & Therapy, Heidelberg, Victoria, Australia. 14. University of Pittsburgh, Department of Psychiatry, Pittsburgh, Pennsylvania, USA. 15. Edith Cowan University, Centre for Precision Health, Joondalup, Australia., 13. The Australian e-Health Research Centre, CSIRO Health and Biosecurity, Parkerville, Victoria, Australia., 11. The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia. 12. Austin Health, Department of Molecular Imaging & Therapy, Heidelberg, Victoria, Australia., 1. Murdoch University, Centre for Healthy Ageing, Health Futures Institute, Murdoch, WA, Australia. 2. Murdoch University, School of Psychology, Murdoch, WA, Australia. 7. Alzheimer’s Research Australia, Ralph and Patricia Sarcih Neuroscience Research Institute, Nedlands, WA, Australia. 17. The University of Western Australia, School of Psychological Science, Crawley, WA, Australia, 7. Alzheimer’s Research Australia, Ralph and Patricia Sarcih Neuroscience Research Institute, Nedlands, WA, Australia. 9. Edith Cowan University, School of Medical and Health Sciences, Joondalup, WA, Australia. 10. The University of Western Australia Medical School, Crawley, WA, Australia., 18. Alzheimer’s Research Australia, The University of Western Australia, Crawley, WA, Australia, 8. Macquarie University, Faculty of Medicine, Human and Health Sciences, Sydney, NSW, Australia. 9. Edith Cowan University, School of Medical and Health Sciences, Joondalup, WA, Australia. 18. Alzheimer’s Research Australia, The University of Western Australia, Crawley, WA, Australia, 1. Murdoch University, Centre for Healthy Ageing, Health Futures Institute, Murdoch, WA, Australia. 2. Murdoch University, School of Psychology, Murdoch, WA, Australia. 7. Alzheimer’s Research Australia, Ralph and Patricia Sarcih Neuroscience Research Institute, Nedlands, WA, Australia.

Part of Topic

Hippocampal volume is significantly associated with a decline in activities of daily living.

•Alzheimer’s disease is characterised by progressive neurodegeneration, including amyloid plaques, tau tangles and brain atrophy.

•Loss of independence in activities of daily living (ADL) is a core clinical feature of Alzheimer’s disease dementia and affects quality of life.

•Structural brain changes on MRI may be linked to loss of independence in daily activities.

•There is a gap in whether the decline in daily functioning is associated with global atrophy or region-specific neurodegeneration.

•In MCI or AD, reduced independence in daily activities was more strongly associated with hippocampal atrophy than with broader measures of brain volume.

•No other volumetric measure was significantly associated with ADL.

Hippocampal integrity uniquely relates to ADL

•Higher ADL scores were associated with greater hippocampal volume, independent of age, sex, amyloid burden, and clinical classification (b = 0.34, p < .001; adjusted R2 = 0.37).

Association persists after adjusting for amyloid burden

•Findings remained significant after controlling for PET amyloid (Centiloid scale), age, sex, and clinical classification.

Decline in ADL may be more closely associated with region-specific neurodegeneration

•ADL performance was not associated with global grey or white matter atrophy or ventricular enlargement.

Associations were specific to hippocampal volume

•ADL performance was not significantly associated with grey matter, white matter volume, or ventricular volume after correction for multiple comparisons.

Sex stratified results

•Higher ADL scores were associated with greater hippocampal volume in males (b = .36, p = .001), while a similar but non-significant trend was observed in females (b = .29, p = .057).

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