Background

Neuropsychiatric symptoms (NPS) are common in older people and may

represent early manifestations of neurodegenerative diseases, particularly

Alzheimer’s disease (AD).

We aimed to investigate the associations between NPS and amyloid

pathology across the AD continuum, considering sex differences, in the

Amyloid Biomarker Study, a large-scale multi-cohort data pooling initiative.

 

Conclusion

This large multi-cohort study shows that the associations of NPS with amyloid

pathology are strongly dependent on both the clinical disease stage and sex. These

results have implication for the understanding of the pathogenesis of NPS in older

adults and for the development of more personalized diagnostic and therapeutic

approaches.