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Alzheimer's Association International Conference 2026

July 12-15, 2026 | London, United Kingdom, and Online

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6960

Analytical Stability Of Brain Health Fluid Biomarkers Using Remote Capillary Blood Collection Methods

Poster Presenter

Owen Swann

Authors

Owen Swann, Sophie Hicks, Caleigh Lynch, Amie Wallman-Jones, Maryam Shoai, Rachel Mulvaney, Bárbara Fernandes Gomes, Eleftheria Kodosaki, Margherita Tecilla, Mazdak Ghajari, Ben Jones, Simon Kemp, TBI-Reporter ,, Richard Sylvester, Matt Cross, Keith Stokes, Mathew G Wilson, David K Menon, Amanda Heslegrave, Henrik Zetterberg, David J Sharp, Thomas D Parker

Affiliations

University College London, University of Cambridge, Imperial College London, Leeds Beckett University, Rugby Football Union, TBI-Reporter, University of Bath, Institute of Sport, Exercise and Health (ISEH)

Part of Topic

Analytical Validation of Minimally Invasive Capillary Blood Microsampling using Tasso+ for Multiplexed Neurological Biomarkers

Backround and Aim

• Blood-based biomarkers are increasingly used to assess brain health, but venous sampling is difficult to deliver repeatedly in remote, field-based or participant-led settings.
• Tasso+ enables minimally invasive upper-arm capillary blood collection, with liquid whole blood collected in under 5 min and processed into plasma or serum.
• A 72 h room-temperature delay reflects the likely time between remote sample collection and laboratory processing.
• Validation is needed to determine whether Tasso+ agrees with matched venous samples and remains reliable after delayed processing.
Aim: To evaluate whether Tasso+ plasma and serum, processed immediately or after a 72 h room-temperature delay, provide reliable measurement of neurological biomarkers compared with venous blood.

Key results

•After a 72 h room-temperature delay, Simoa GFAP and NfL showed strong agreement with matched venous plasma and serum.
•Alamar NULISAseq showed protein-dependent agreement in plasma and serum, with GFAP and NPTX2 showing high agreement and NfL moderate agreement.
•Multiplex proteomic agreement varied by analyte, supporting protein-specific validation before wider use.

Tasso+ device

•Tasso+ is a minimally invasive upper-arm capillary blood collection device.
•It uses a small lancet and gentle vacuum to collect liquid whole blood into a detachable tube.
•Samples can be collected in under 5 min, supporting rapid field-based or participant-led sampling.

Conclusions

•Tasso+ enables rapid, minimally invasive capillary blood collection for neurological biomarker studies outside traditional clinical settings.
•GFAP and NfL showed strong agreement with matched venous samples after a 72 h room-temperature delay, supporting delayed processing workflows.
•These findings support Tasso+ for remote, field-based and participant-led sampling, while highlighting the need for analyte-specific validation before broader implementation.
•These findings provide a validated sampling framework for the MRC-funded TBI-TS study, which will use Tasso+ to support scalable biomarker collection across 600 professional rugby players and investigate sport-related TBI as a risk factor for neurodegenerative disease and dementia.
 


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