4,068 posters, 219 videos, 101 topics, 69 sessions, 14,365 authors, 6,128 institutions
ePostersLive by SciGen Technologies S.A. All rights reserved.
Alzheimer's Association International Conference 2026
July 12-15, 2026 | London, United Kingdom, and Online
3745
Pathology-specific And Pathology-agnostic Peptide Associations Across Neurodegenerative Disease Pathologies
Poster Presenter
Authors
Affiliations
Part of Topic
- Synaptic dysfunction is a central feature across neurodegenerative diseases and is strongly associated with cognitive outcomes
- Our understanding of which aspects of synaptic functioning are common versus distinct across neuropathologies is limited in humans
- How do synaptic proteomics relate to neuropathology and cognition in older adults?
- Early AD Hallmark: Synaptic dysfunction is an early, central characteristic of Alzheimer's disease
- Unique LBD Signatures: Lewy Body Disease showed most etiology-specific synaptic peptide profile among non-AD pathologies examined
- Attenuated Non-AD Signaling: Signal outside AD pathways (TDP-43/Vascular) shows smaller synaptic associations
- Drivers of Cognitive Resilience: A subset of four neuronal pentraxin proteins explains significant cognitive variance independent of demographic covariates and neuropathology
- Pathology-Agnostic Therapeutics: These highly conserved, pathology-agnostic synaptic pathways highlight promising broad-spectrum therapeutic targets
Comments
Email is required but is not shown publicly.
Loading comments...