Machine Learning Identifies a Correlation Between Damage to the Axon Initial Segment and Tau Pathology in Progressive Supranuclear Palsy

Merci N. Best1,2, Amber Spencer1, Jonathan Levy1, Kalynn M. Harvey1, Mimi Li1, Florence U. Johnson1, Meghan Dailey1, Einar B. Olafsson1, Jacob Waksmacki1, Benjamin S. Halligan1, Max Garcia1, Michael Bekier1, Jian Kang1, Paul Jenkins1, Vern B. Carruthers1, Bruno Giordani1, Jonathan Z. Sexton1, Benjamin L. Wolozin2 and Henry L. Paulson1 | 1University of Michigan and 2Boston University

Axon initial segment damage may contribute to neuronal dysfunction and tau-mediated neurodegeneration.

PROTEIN LEVELS

TAU TANGLES

AXON INITIAL SEGMENT

CORRELATION

CONCLUSION