Introduction

Neuropsychiatric symptoms (NPS) are common in cognitive decline and

Alzheimer's disease (AD), yet the underlying pathology is poorly understood.

We investigated cerebrospinal fluid (CSF) proteome and metabolome

alterations to identify CNS pathophysiological alterations related to

(a) the overall presence of NPS

(b) the presence of depression, anxiety, and apathy

 

Conclusion

Applying a multi-omics approach, we identified distinct CSF molecular

alterations suggesting specific biological pathway alterations in

depression, apathy, and anxiety. Further external validation and the

investigation of less frequent symptoms such as agitation, disinhibition,

or psychosis are needed.