Loading...

4,068 posters, 219 videos, 101 topics, 69 sessions, 14,365 authors, 6,128 institutions

ePostersLive by SciGen Technologies S.A. All rights reserved.

Alzheimer's Association International Conference 2026

July 12-15, 2026 | London, United Kingdom, and Online

Alzheimer's Association International Conference 2026 banner

10498

Short-Term Blood Pressure Variability is Associated with the Progression of Enlarged Perivascular Space Burden

Poster Presenter

James LeFevre

Authors

James D. LeFevre, W. Hudson Robb, Dandan Liu, T. Bryan Jackson, Kimberly R. Pechman, Niranjana Shashikumar, Yukti Vyas, Bennett A. Landman, L. Taylor Davis, Timothy J. Hohman, Angela L. Jefferson

Affiliations

Vanderbilt Memory and Alzheimer’s Center, Vanderbilt University School of Medicine, Nashville, TN, USA; Vanderbilt Alzheimer’s Disease Research Center, Nashville, TN, USA; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA, Vanderbilt Memory and Alzheimer’s Center, Vanderbilt University School of Medicine, Nashville, TN, USA; Vanderbilt Alzheimer’s Disease Research Center, Nashville, TN, USA, Vanderbilt Memory and Alzheimer’s Center, Vanderbilt University School of Medicine, Nashville, TN, USA; Vanderbilt Alzheimer’s Disease Research Center, Nashville, TN, USA; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA;, Vanderbilt Memory and Alzheimer’s Center, Vanderbilt University School of Medicine, Nashville, TN, USA; Vanderbilt Alzheimer’s Disease Research Center, Nashville, TN, USA; Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA, Vanderbilt Memory and Alzheimer’s Center, Vanderbilt University School of Medicine, Nashville, TN, USA; Vanderbilt Alzheimer’s Disease Research Center, Nashville, TN, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA, Vanderbilt Memory and Alzheimer’s Center, Vanderbilt University School of Medicine, Nashville, TN, USA; Vanderbilt Alzheimer’s Disease Research Center, Nashville, TN, USA; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA, Vanderbilt Memory and Alzheimer’s Center, Vanderbilt University School of Medicine, Nashville, TN, USA; Vanderbilt Alzheimer’s Disease Research Center, Nashville, TN, USA; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA

Part of Topic

Background

•Enlarged perivascular spaces (ePVS) are a key marker of cerebral small vessel disease and may reflect impaired perivascular waste clearance.
•Greater short-term blood pressure (BP) variability, defined as fluctuations in BP over 24 hours, may drive ePVS development by promoting vascular dysfunction.
•While increased BP has been strongly linked to greater ePVS burden, the effect of BP variability on ePVS burden remains unclear.
•We investigated whether short-term BP variability relates to the progression of ePVS burden in older adults.

Methods & Analysis Plan

•Vanderbilt Memory and Aging Project participants free of clinical dementia and stroke (n=463, 69±9 years, 48% female) underwent 3T multimodal MRI serially over a 9-year follow-up period. See Table 1.
•An nnU-Net based deep learning segmentation tool, Detection Of Regions of Enlarged perivascular Spaces (DORES), was used to segment and quantify ePVS burden within the white matter and basal ganglia.
•Participants underwent 24-hour Ambulatory Blood Pressure Monitoring (ABPM) capturing systolic and diastolic BP every 30 minutes to calculate 24-hour average real variability (ARV).
•Linear mixed-effects models tested the effect of baseline short-term BP variability on the annual change in ePVS burden.
•Models were adjusted for age, sex, race/ethnicity, education, cognitive status, Framingham Stroke Risk Profile (minus age), APOE-ε4 status, intracranial volume, antihypertensive use, and mean BP, and corrected for multiple comparisons using the False Discovery Rate (FDR).

Results

•Baseline ARV of diastolic variability showed no significant association with the progression of ePVS burden in either the white matter or basal ganglia (p-valuesFDR>0.05).
•Higher baseline ARV of systolic BP was significantly associated with a slower annual progression of white matter ePVS burden (p-valuesFDR<0.01). See Figure 1.
•ARV of systolic BP was not significantly associated with the progression of basal ganglia ePVS burden. See Figure 2.

Conclusions

•Contrary to our hypothesis, greater short-term systolic BP variability was associated with slower progression of white matter ePVS burden over time.
•These paradoxical associations warrant further investigation of confounding variables and selection bias.

Comments

Email is required but is not shown publicly.

Loading comments...

aaic2026 banner
Copyright © 2015-2026, ePostersLive® SciGen is a registered trademark of SciGen Technologies S.A. Patent pending.

This website and third-party tools we use rely on cookies for the best user experience. By selecting "I agree", you agree to cookie usage as described in our Privacy Policy.