4,068 posters, 219 videos, 101 topics, 69 sessions, 14,365 authors, 6,128 institutions

Alzheimer's Association International Conference 2026

July 12-15, 2026 | London, United Kingdom, and Online

11083

Associations Between Daytime Napping And Longitudinal Tau Accumulation In The Preclinical Alzheimer’S Disease Continuum

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Poster Presenter

Idris Demirsoy

Authors

Idris Demirsoy, Ali Ezzati

Affiliations

Usak University, Department of Neurology, University of California, Irvine, CA, USA; Alzheimer's Disease Research Center, Institute for Memory Impairments and Neurological Disorders (UCI MIND), University of California, Irvine, CA, USA; Department of Epidemiology and Biostatistics, University of California, Irvine, CA, USA

Part of Topic

Associations Between Daytime Napping and Longitudinal Tau Accumulation in the Preclinical Alzheimer’s Disease Continuum

Objective: To determine whether self-reported daytime napping duration predicts longitudinal regional tau PET burden and cognitive trajectories in a biomarker-stratified preclinical cohort.

TAKE AWAY

* Long nappers have higher tau at every visit across 4.7 years, but the gap does not widen, napping predicts existing tau burden, not the rate of accumulation (all trajectory terms null).

* The napping–tau association is amyloid-independent (Aβ+: β=0.056, p=0.007; Aβ−: β=0.053, p=0.038; moderation LRT p=0.959), consistent with tau accumulating in wake-promoting neurons before significant cortical amyloid involvement.

* Existing medial temporal tau burden fully mediates the association between habitual long napping and future cognitive decline (indirect: β=−0.203, p=0.032; direct beyond tau: p=0.646).

* Reverse causation, not confounding: the signal lives in stable between-person napping patterns (p=0.036), not visit-to-visit fluctuations (p=0.130)

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