4,068 posters, 219 videos, 101 topics, 69 sessions, 14,365 authors, 6,128 institutions
ePostersLive by SciGen Technologies S.A. All rights reserved.
Alzheimer's Association International Conference 2026
July 12-15, 2026 | London, United Kingdom, and Online
9000
Modifiable Risk Factors Associated With Alzheimer's Disease Pathology: Evidence From A Population-based Autopsy Study
Part of Topic
Modifiable Risk Factors Associated With Neuropathologically Confirmed Alzheimer's Disease and Vascular Dementia Pathology
Cintia Monteiro Carvalho1; Regina Paradela1; Renata Elaine Paraizo Leite1; Carlos A Pasqualucci1; Eduardo Ferriolli1; Lea T Grinberg1, 2; Claudia Kimie Suemoto1,3.
1 Universidade de São Paulo, Brazil. 2 Mayo Clinic, USA. 3 The University of Texas at San Antonio, USA.
Modifiable risk factor profiles may differ by dementia etiology, with depression and physical inactivity associated with AD pathology, while traumatic brain injury, hypertension, and diabetes were associated with VD pathology, suggesting a role for etiology-specific dementia prevention strategies.
-
Dementia prevention increasingly targets modifiable risk factors.
-
Most evidence is based on clinical diagnoses, which have limited etiological specificity.
-
Neuropathology allows more accurate differentiation between Alzheimer's disease (AD) and vascular dementia (VD).
-
We examined associations between modifiable risk factors and neuropathologically confirmed AD and VD.
-
Cross-sectional study using NACC (USA) and BAS (Brazil).
-
AD: 6,020 participants.
-
VD: 2,745 participants.
-
2,068 controls shared between analyses.
-
Mixed AD–VD cases excluded.
-
13 modifiable risk factors assessed.
-
Logistic regression adjusted for age, sex, and factor-specific confounders.
-
AD and VD showed distinct risk factor profiles.
-
Findings highlight the importance of considering dementia etiology when targeting prevention strategies.
Comments
Email is required but is not shown publicly.
Loading comments...