ØModifiable risk factors were surveyed in 72 older adults (Figure 3) participating in a cohort study at Cedars-Sinai Medical Center.

ØPrevalence of modifiable risk factors were examined and cross-tabulated across distinct regions of LA referred to as Service Planning Areas (SPAs).

ØStrong Prevalence: Hypertension (60-80%), hypercholesterolemia (61-88%), alcohol use (57-71%), hearing loss (61-67%), vision loss (61-70%), and social isolation (54-71%) were prominent across regions. In 5 out of 6 regions, ≥3 risk factors were endorsed by ≥50% of individuals (Figure 4).

ØModest Prevalence: Physical inactivity (0-14%), cigarette smoking (11-43%), and low education (0-3%) were low in each area.

ØRegional Differences: There was regional heterogeneity with substantially higher obesity rates in the San Gabriel Valley (57% vs 0-14%) and hypertension (86% vs. 27-56%) and hypercholesterolemia (88% vs. 27-67%) in Metro LA.

ØModifiable dementia risk factors were prevalent across Los Angeles Service Planning Areas, with most regions exhibiting multiple risk factors affecting a substantial proportion of participants; hypertension, hypercholesterolemia, hearing loss, social isolation, vision loss, and alcohol use were among the most commonly reported risk factors.

ØDistinct regional patterns emerged, including elevated obesity and TBI in the San Gabriel Valley and higher rates of hypertension and hypercholesterolemia in Metro LA.

ØThese findings highlight the importance of considering local and community-specific risk profiles when developing dementia prevention and risk-reduction strategies.

ØExpand recruitment across Los Angeles Service to increase sample size and improve representation of diverse communities

ØInvestigate how clusters of modifiable risk factors interact and influence longitudinal cognitive outcomes and incident dementia.