Early Adult Exosomes Reverse Aging-Associated Endothelial Transcriptional Networks in Alzheimer’s

Serum exosomes from early adult donors (18-25 years) reverse the aging transcriptional signature that late-adult donors (65-72 years)
exosomes impose on human brain microvasculature endothelial cells, restoring mitochondrial and ribosomal programs and suppressing inflammatory and junctional remodeling linked to blood-brain barrier breakdown in Alzheimer’s disease.