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Alzheimer's Association International Conference 2026

July 12-15, 2026 | London, United Kingdom, and Online

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3708

Asymmetric Functional Connectivity Of The Default Mode Network In Perimenopause

Poster Presenter

Sophia Moret

Authors

Sophia Moret, Wen-Xiang Tsai, Jordan A. Galbraith, Carolyn A. Fredericks

Affiliations

Yale School of Medicine

Part of Topic

Background:
Alzheimer’s disease (AD) is the leading cause of dementia and two-thirds of those affected are women1 
The DMN is highly implicated early in AD pathology and shows sex-related differences in midlife, including higher connectivity in women aged 40-503
In cognitively impaired individuals, DMN regions, including the posterior cingulate cortex, posterior inferior parietal lobule, and angular gyrus, show reduced left lateralization relative to cognitively normal adults2
Sex differences in DMN laterality remain largely unexplored, despite its relevance to women’s increased AD risk
 
Methods:

Cognitively normal adults from the Human Connectome Project-Aging dataset were analyzed4

A 30-component group ICA was run on resting-state fMRI data, followed by dual regression

Schaefer 2018 DefaultA/B/C masks identified DMN submodule components

Laterality indices were calculated as (Left − Right) / (Left + Right), with positive values indicating left-lateralization

Sex and Sex × Submodule effects were tested across DefaultA, DefaultB, and DefaultC

Conclusion:

DMN submodules showed distinct lateralization profiles across males and females
DefaultA was right-lateralized, while DefaultB and DefaultC were left-lateralized
Sex differences were modest, with males showing significantly greater rightward DefaultAlaterality than females
DefaultA includes DMN areas previously linked to altered lateralization in cognitive impairment
Findings suggest DMN laterality is submodule-specific, with sex-related differences most apparent in DefaultA
 
Future directions:

Test associations between DMN submodule laterality and hormone levels
 
Explore whole-network DMN connectivity beyond hemispheric laterality

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