Percutaneous Tumor Ablation:Cryoablation Facilitates Targeting of Free Epirubicin–Ethanol–Ioversol Solution Interstitially Coinjected in a Rabbit VX2 Tumor Model
Xiaofeng He,Yueyong Xiao,Xiao Zhang,Xiaobo Zhang,Xin Zhang,Xuyang Ma,Yingtian Wei
Chinese PLA General Hospital,100853
Object:This acute study was aimed at exploring the ability of a cryoablative lesion to drive the distribution of a concomitant in situ injection of a freeepirubicin-ethanol-ethiodol-methylene blue mixture. We report the feasibility and safety of this new percutaneous computed tomography-guided combinatorial ablative procedure on VX2 tumors.
Methods:Eight New Zealand white rabbits bearing 16 tumors on both side of the back muscle were simultaneously treated on the same day under image-guidance: (1) 8 concomitant cryoablation and interstitial chemotherapy and, (2) 8 intratumor marginal chemotherapy. For the latter, an injection needle was positioned at the inner distal margin of a selected tumor where the chemotherapy was delivered, during 5 serial sequences. For the concomitant therapy a single cryoneedle maintained the ice front at the tumor margin where a needle delivered the drug dose during 5 freeze–injection-thaw sequences.
Results:Enhanced computed tomographyscans and histopathologyon day 3, 7 and 10 assessed the tumor contours and the tracer localization.During the concomitant therapy the ioversol and the dye distributed at the tumor and ice ball margins. Post-operative images showed a focal marginal enlarging defect that coincided with necrosis at histopathology and grander growth inhibition compared to the chemotherapy group.
Conclusion: The intratumor chemotherapy had the tracers contained in the tumor without any marginal necrosis. Our image-guided concomitant therapy is feasible and may enhance the effectiveness ofa free epirubicin-tracer mixture at the tumor margin in this VX2 tumor model.