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Poster 74
Genetic Variation in Vascular Morphology Affects Plasmonic Nanoparticle Uptake, Temperature Distribution, and Efficacy of Photothermal Ablation of Breast Cancer

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Title: Genetic variation in vascular morphology affects plasmonic nanoparticle uptake, temperature distribution, and efficacy of photothermal ablation of breast cancer



Plasmonic photothermal therapy (PTT) with ~100nm nanoparticles (NPs)  relies on enhanced retention and permeation (EPR) based trapping of systemically delivered NPs through aberrant vasculature of solid tumors. While the impact of tumor type on nanomedicine has been investigated, the effect of varying host vasculature has not been studied in regards to its impact on PTT efficacy. We report the impact of host vascular disorganization on gold nanorod (GNR) uptake, thermal response to near-infrared (NIR) radiation, and treatment efficacy in rat based Consomic xenograft models (CXM) of human triple negative breast cancer.




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