Objective: Feasibility of imaging of acute hypoxia with 18F-misonidazole in the liver post transarterial embolization with LUMITM combined with DEBTACE.
Methods: Three consecutive embolization-naïve patients with primary (n=2) or metastatic (n=1) liver tumors were prospectively enrolled and underwent DEBTACE with LC Beads containing doxorubicin plus TAE with bland LUMI microspheres to a near complete flow stasis endpoint. PET-CT imaging was performed 24-72 hours after embolization with 18F-misonidazole 0.1mCi/kg. PET-CT images were obtained 2 hours following radiopharmaceutical injection
NIH Intramural Research Program, NIH Center for Interventional Oncology Grant ZID BC011242-08
RSNA Foundation Research Seed Grant
Collaborative Research and Development Agreement (BTG)