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Poster 24
Dosimetric Analysis of Yttrium-90 (90Y) Glass and Resin Microsphere Distributions in Hepatic Tumors: From the Microsphere Coverage to the Absorbed Dose

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Dosimetric Analysis of 90Y Glass and Resin Microsphere Distributions in Hepatic Tumors:
From the Microsphere Coverage to the Absorbed Dose

T. Mauxion1, A. Fischer2, M.R. Dreher1, R. Salem3

1PhD, Biocompatibles UK Ltd, a BTG International group company;2 PhD, Philips Research; 3 MD, Northwestern University, Chicago (IL)

 

Study Objective

The objective of this study was to investigate the microsphere and absorbed dose (AD) tumor coverage for typical resin (50 Bq/MS ) and  glass (2500 Bq/MS) radioembolization  scenarios.

 

Methods: Patient and Microsphere Characteristics

Right lobe1: Perfused volume=1302 mL; T:N=2

Glass: Standard dosimetry (MIRD Schema)

Resin: Body Surface Area (BSA) and Partition Model (PM) ; Average BSA2 for adults = 1.79 m2

 

Results

Tumor Absorbed Dose Coverage (D95) was Higher for Glass than Resin

•Tumor AD distribution was more uniform (i.e., narrow peak) for Resin  (D95/Dmean = 87%) than for Glass (D95/Dmean = 82% to 86%)
•Tumor absorbed dose coverage (D95) is greater for Glass than Resin
 
Conclusions

Microsphere coverage (MS/cc) increased with the number of MS administered, resulting in greater MS coverage for Resin than Glass and a slightly more uniform tumor absorbed dose

 

 
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