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IS-9
SUBCUTANEOUSLY ADMINISTERED LEUPROLIDE ACETATE CONSISTENTLY ACHIEVED AND MAINTAINED LOW T SUPPRESSION AND NADIR T LEVELS ≤5NG/DL REGARDLESS OF AGE AND WEIGHT

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Subcutaneously Administered Leuprolide Acetate Consistently Achieved and Maintained Low Testosterone Suppression and Nadir Testosterone Levels ≤5 ng/dL Regardless of Age and Weight

INTRODUCTION

  • Achieving and maintaining testosterone (T) suppression to castration level is the cornerstone of androgen deprivation therapy (ADT) for advanced prostate cancer (PCa)

  • Using modern assay methodology, median T level after castration is 15 ng/dL; the European Association of Urology guidelines define target levels for castration as T≤20 ng/dL

  • Studies demonstrated that reaching nadir T<20 ng/dL is correlated with improved clinical outcomes such as time to progression or disease specific survival

  • As it is important to maintain castrate T levels during ADT, it is of interest to understand if factors such as age or body weight (BW) should be considered when selecting a therapy

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