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ID 6681Plateled reached plasma (PRP) as a treatement of Lichen sclerosus in premenopausal and postmenopausal woman
Damir Franic (SI) school of medicine university of maribor
Zlatko Iternicka (SI) Department of Pathology and Cytology, General Hospital Celje, Celje, Slovenia
Maja Franic-Ivanisevic (RS) Clinic of Gynecology and Obstetrics, Clinical Center Serbia, Belgrade, Serbia
Background: Regenerative Medicine represents a shift toward more affordable, approachable strategies for tissue restoration. Platelet rich plasma (PRP) is used in treating Female Sexual Dysfunction (FSD) helping activate female orgasm system, as supportive therapy after laser treatment of stress urinary incontinence and vaginal rejuvenation and in treating lichen sclerosus . Methods. The physician draws a small amount of venous blood and isolates the red cells from a platelet concentrate, embedded in its own plasma. For the treatment of LS RegenKit Cellular Matrix was used. After the collection of blood, the centrifugation (5 min at 5000 rpm) is necessary to separate the PRP from the red cells. Before the application of PRP, anesthetic gel is deposited. Four ml of PRP are injected subdermally with a thin needle of 23 G in the region affected by LS. Patients: Two women with lichen sclerosus was treated with PRP. One were postmenopausal (66 y) and the other were premenopausal (37 y). The symptoms and image of lichen sclerosus, prior and after the treatment were objectivized with ICIQ-VS validated questionnaire and with histology before and after the PRP treatment. PRP was applied twice in a period of 3 months and then for maintain the regeneration of the skin, once a year. Results. The post-treatment shows near normal epidermis with returned upper dermal cellularity. The patient feels comfortable, with no symptoms, her sex drive has returned, and her quality of life has increased significantly. The weighted score concerning ICIQ-VS decreased from 42 to 7, and affected QoL from 8 to 0. Conclusion. PRP is a new treatment option for LS in women as it improves regeneration of the LS affected region. Therefore, besides cessation of symptoms, the woman may expect complete regeneration of the affected region, which has not been achieved with therapy options available, so far.