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CT04
Risk Factors for Viral Infections following Haploidentical Hematopoietic Stem Cell Transplantation (Haplo-SCT) with Post-Transplant Cyclophosphamide (PTCy) in Patients with various Hematologic Disorders: A Single Center Experience

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RISK FACTORS FOR VIRAL INFECTIONS FOLLOWING HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANTATION  WITH POST-TRANSPLANT CYCLOPHOSPHAMIDE IN PATIENTS WITH VARIOUS HEMATOLOGIC DISORDERS:  A SINGLE CENTER EXPERIENCE

Haploidentical hematopoietic stem cell transplantation (haplo-HCT) with post-transplant cyclophosphamide (PTCy) increases the donor pool for allogeneic HCT but is associated with significant early viral reactivation.  Current factors implicated in viral reactivation following haplo-HCT include:  T-cell depletion (in-vivo or ex-vivo), use of PTCy, human leukocyte antigen (HLA) disparity, and grades II-IV acute GVHD.  The incidence of cumulative viral reactivation following haplo-HCT using bone marrow (BM) has been reported as 77% at 1-year (CMV 54%, EBV 37% and BK cystitis 19%) in at risk patients. However, limited data exists on viral reactivation rates based on a peripheral blood stem cell (PBSC) source.  We hypothesized that haplo-HCT with PTCy using PBSC will mitigate early viral reactivation as compared to BM.

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