Acute hematogenous knee PJI is a limb- and implant-threatening

complication. DAIR preserves well-fixed components and reduces

surgical burden, while DAPRI adds local antibiotic-loaded calcium

sulfate beads. Failure remains common and patient selection is

crucial.

Nearly one-third of patients required further surgery

within 12 months after DAIR or DAPRI.

Failures had higher BMI and lower preoperative hemoglobin,

albumin and PNI in exploratory univariate analyses.

CLINICAL MESSAGE: host optimization deserves attention

when planning implant-retention treatment.