TITLE: Early versus Late Periprosthetic Femur Fractures After Total Hip Arthroplasty: A Comparative Analysis of Infection and Reoperation Outcomes
Mitchell Kennedy BS, Andrew Li BA, David Novikov MD, Vinay K. Aggarwal MD, Ran Schwarzkopf MD MSc
Department of Orthopedic Surgery, NYU Langone Health, New York, NY
BACKGROUND
Periprosthetic femur fractures (PFFs) after total hip arthroplasty (THA) represent a growing burden with substantial morbidity, mortality, and economic costs to healthcare systems and patients
Whether fracture timing impacts postoperative complications, specifically periprosthetic joint infection (PJI), remains unclear
OBJECTIVES
Compare PJI and septic reoperation rates of early (<90 days) versus late (>90 days) PFFs following THA
METHODS
Retrospective review of 133 surgically repaired PFFs following primary THA (2011 – 2025)
Exclusion criteria: fractures not involving the femoral stem, pathologic fractures, active PJI at time of fracture, prior revision before PFF surgery, and <1-year follow-up
Patients were stratified into early (<90 days, n=103) and late (>90 days, n=30) PFF cohorts relative to the index THA
Primary outcomes: overall PJI incidence, septic reoperations, and PJI-specific 90-day readmissions; Kaplan-Meier analysis was used to estimate septic reoperation-free survivorship
RESULTS
Incidence of PJI was similar between early and late PFFs; time to septic reoperation also did not significantly differ between early and late PFFs (P=0.483)
Overall 90-day readmissions did not differ between groups; readmissions for PJI were also similar (P=0.865)
Late PFFs were associated with longer operative times (P=0.004)
Kaplan-Meier analysis demonstrated no differences in survivorship free from septic reoperation up to three years postoperatively
CONCLUSIONS
Timing of PFF following THA did not significantly impact rates of PJI, septic reoperation, or infectious survivorship
Overall infectious complication profiles remained similar between early and late PFF populations
These findings suggest fracture timing alone should not guide the infectious prognosis or management of early PFFs