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Title: Precision CRISPR/Cas-Based Antimicrobials for Selective Elimination of Pathogenic Staphylococcus Species
Summary: We present a precision medicine strategy using CRISPR/Cas9 to target a lineage-specific bacterial protein biosynthesis pathway. Utilizing a custom automated bioinformatics pipeline, we designed highly specific guide RNAs that selectively eliminate pathogenic Staphylococcus aureus without cross-reacting with beneficial human microbiota or host cells, bypassing traditional antibiotic resistance bottlenecks.
Keywords: CRISPR therapeutics; Superbugs; Bioinformatic pipeline; Staphylococcus; Targeted antimicrobials; Species-specific.