Synthesis and Characterization of Histidine derived Sulphonamides bearing Carboxamides functionality

A. C. Achigamonye, U. C. Okoro and A. E. Onoabedje

INTRODUCTION

Plasmodium species like falciparum, vivax, malariae, ovale and Knowlesi are responsible for the protozoan disease know as malaria. Sulphonamides and its corresponding carboxamide analogoues have been widely used in medicinal chemistry due to their low cost, strong biological activity and moderate toxicity.