Title: Evaluation Of Medicinal Properties Of Selective Phytochemicals From Soy And Pea As Anti-inflammatory Agents

Authors: Mala Parab *, Sayed Mehrukh Fatma, Debjani Dasgupta, Pramodkumar P Gupta *

Affliation: School of Biotechnology and Bioinformatics, D Y Patil Deemed to be University, Navi Mumbai, Maharashtra, India.

email: malaparab@gmail.com/mala.parab@dypatil.edu/pramod.gupta@dypatil.edu/pramodkumar785@gmail.com

Abstract:

Inflammation is a complex physiological response that plays a crucial role in various diseases, including chronic inflammatory conditions. Natural compounds such as genistein found in soy and pea, have gained considerable attention due to their potential therapeutic benefits. This study aimed to evaluate the anti-inflammatory effects of soy and pea extracts containing genistein and their interaction with TNF-alpha, a key proinflammatory cytokine. The in-silico analysis revealed anti-inflammatory activity of genistein by attenuating TNF-alpha-induced inflammation. Employing in-vitro cell line model- based analysis, the extracts and genistein were observed to suppress the activation of NF-κB, a transcription factor crucial for inflammatory responses. Additionally, cell viability assays demonstrated that the treatments did not exert cytotoxic effects on the cells. The present study also highlights the significant antioxidant activity exhibited by soy and pea due to their rich content of bioactive compounds. These compounds have been shown to scavenge free radicals, reducing oxidative stress and potentially preventing various chronic diseases

Key words: Soy, Pea, Cytokines, NF-κB, TNF-alpha, free radicals.

Aims and Objectives:

The aim of present study is gauge the medicinal properties of soy (Glycine max) and pea ( Pisum sativum).

The objectives were to

Overall, this thesis aims to contribute to the growing body of knowledge on the medicinal properties of soy and peas

Conclusion: