4th Commonwealth Chemistry Posters

Coumarinolignoid and indole alkaloids from the roots of the hybrid plant Citrus × paradisi Macfad (Rutaceae) and research of anticancer compounds.

INTRODUCTION

Citrus × paradisi (C.P) is a hybrid of Citrus maxima (Burm.) Merr. and Citrus sinensis (L.) Osbeck. The plant is reputed for its use as a local treatment of an array of human diseases. For example, it is believed to be effective in cancer prevention, cellular regeneration, lowering cholesterol, detoxification and heart health maintenance. [1-3]. Our recent work on the MeOH extract of the stem bark of C. × paradisi led to the isolation of a 23-S-isolimonexic acid derivative, as well as coumarin and acridone alkaloids.[4] Here, as part of our continuous study of the phytochemistry and pharmacology of the genus Citrus, we present the results of the chemical and biological investigation of the MeOH extract of the roots of the hybrid species C. × paradisi.

OBJECTIVE

Isolate and identify compounds from hybrid plant with anticancer activities.

RESULTS

New compounds isolated (1 and 2) and 10 known. The MeOH extract showed significant cytotoxity activities againt human adenocarcinoma alveolar basal epithelial A549 and Caucasian prostate adenocarcinoma PC3 cell lines, with IC50 values of 35.2 and 38.1 µg/mL, respectively; the 7 compounds showed weak activity, with IC50 values of 99.2 to 250.2 µM and 99.5 to 192.7 µM, respectively.

CONCLUSION

7 compounds identified with potential anticancer activity

4th Commonwealth Chemistry Posters

Coumarinolignoid and indole alkaloids from the roots of the hybrid plant citrus × paradisi Macfad (Rutaceae)

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