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Confocal laser endomicroscopy for bladder cancer diagnosis: Our initial experience


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Confocal laser endomicroscopy for bladder cancer diagnosis: our initial experience

EIML Liem, JE Freund, CD Savci-Heijink, J Baard, GM Kamphuis, MP Laguna Pes, DM de Bruin, TG van Leeuwen , TM de Reijke, JJMCH de la Rosette

Academic Medical Center, Amsterdam, The Netherlands


Introduction & objective

During endoscopic evaluation of the bladder, no direct histopathologic information can be obtained. Confocal Laser Endomicroscopy (CLE) is a high-resolution optical imaging technique that allows for real-time high resolution microscopic images.

Objective: to evaluate our initial experience of confocal laser endomicroscopy for bladder cancer diagnosis



38 tumours

▪  6    Benign

▪  19  Low-grade UC

▪  11  High-grade UC

▪  2    Carcinoma in Situ



•   Interobserver agreement for CLE based diagnosis for bladder tumours is substantial (84%, κ=0.74)

•   Concordance between CLE based diagnosis and histopathology is moderate (74%, κ=0.58)

•  CLE images provide information on histopathologic features and could potentially enable real-time tumour grading during cystoscopy

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