The Potential of Nanofabricated Denture Surface for Prevention of Denture Stomatitis
Denture stomatitis (DS) is a common disease affecting denture wearers that is frequently associated with colonization by pathogenic microbial biofilms, of which Candida spp. predominate (Gendreau & Loewy, 2011). Strategies to minimise this are urgently required to reduce the prevalence of this condition. Taking lessons from nature such as the lotus leaf, cicada wings and shark skin, where microbial colonization can be limited by natural modification of surfaces on a micro and nano scale (Hasan et al., 2013, Diu et al., 2014, Song et al., 2015). Then, we can use these same principles to modify the surface of the biomedical materials used in denture construction to obtain an antimicrobial effect.
Hypothesis and Aims
We hypothesise that nanoscale modification of denture base materials will prevent or reduce microbial adhesion. We developed and tested nano-indented materials and quantified the effect on the adhesion capacity of Candida albicans.
These data show that PMMA surfaces can be modified on a nanoscale and that these modified surfaces have the potential to inhibit biofouling of the dental prosthesis. Nanoscale modification surfaces could be used to improve oral mucosal health in denture wearers.