MicroRNAs (miRNAs) represent a class of small non-coding RNAs that mediate gene expression at the posttranscriptional level. Dysregulation of miRNAs is potentially dangerous and may lead to different malignant processes including oral carcinogenesis. Oral squamous cell carcinoma (OSCC) is the eighth most common cancer worldwide, with a high rate of recurrence. Previous studies have linked the aberrantly expressed microRNAs (miRNAs) with the development of oral squamous cell carcinoma (OSCC)1. Despite considerable gain of knowledge for its early diagnosis and treatment, this type of cancer remains one of the most lethal neoplasm because of the local invasiveness and high risk of lymph node metastasis2. Thus, deciphering of molecular mechanisms that govern this type of malignancy will support the development of better therapeutic strategies.