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The Addition of ACB and IPACK to PAI Enhances Postoperative Pain Control in TKA: a Randomized Controlled Trial
Session: MP-05b
Fri, April 20, 8-9:30 am
Uris (Shubert Complex), 6th floor

Please note, medically challenging cases are removed three months after the meeting and scientific abstracts after three years.


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The addition of ACB and IPACK to PAI enhances postoperative  pain control in TKA: A randomized controlled trial.

Kim, David MD, Beathe, Jonathan MD, Lin, Yi MD PhD, Oxendine, Joseph MD, Maalouf, Daniel MD MPH, Goytizolo, Enrique, MD, Garnett, Christopher BA, Ranawat, Amar MD, Su, Edwin MD, Mayman, David MD, Westrich, Geoffrey MD, Alexiades, Michael MD, YaDeau, Jacques MD PhD, Memtsoudis, Savros, MD PhD


The management of postoperative pain in total knee arthroplasty (TKA) patients remains both challenging and crucial to this procedure’s success. With the rapid rise of ambulatory joint replacement surgeries, enhanced recovery after surgery (ERAS), and “fast-track” programs, many centers are seeking optimal analgesic pathways to ensure timely discharge and prevent unanticipated admissions for pain control. Although periarticular injections (PAI) have gained widespread popularity, their ability to provide adequate pain control remains limited.  Motor sparing peripheral nerve blocks such as the adductor canal block (ACB) and interspace between the popliteal artery and capsule of the posterior knee (IPACK) block are being considered as value added procedures, but supporting literature remains rare. 


The authors hypothesized that these augmentative motor-sparing blocks can significantly lower pain on ambulation in the early postoperative period compared to the use of PAI alone, thus facilitating rehabilitation.


In this IRB-approved (2016-0168) double-blinded randomized controlled trial, eighty-six patients undergoing TKA gave informed written consent and were randomly assigned to receive either (1) a PAI (control,n=43), or (2) an IPACK with an ACB and “modified” PAI injection  (intervention,n=43).  The primary outcome was pain on ambulation on postoperative day 1.  Secondary outcomes included NRS pain scores, pain outcomes, and opioid consumption.


On POD 1, intervention group  reported  lower numeric rating scale (NRS) pain scores on ambulation, than control group(1.7 versus 5, p <0.001) .  The difference in pain scores on ambulation was also found to be significant on POD 0 (1.7 versus 5.2, p < 0.001), and POD 2 (4.5 versus 5.5, P = 0.033).  Intervention group also reported significantly lower pain scores after physical therapy (PT) on POD 0 and 1 (1.9 and 1.4, p < 0.001).   There was no difference in hospital length of stay, however, more patients in the IPACK group were discharged on POD 0 (5%) and POD 1 (19%) than the PAI alone group (none on POD 0 and 16% on POD 1). There was no difference in Physical Therapy ambulation distance on PACU, POD 1 and POD 2. 


By adding the IPACK block and the ACB to the PAI, patients received significantly better pain control on postoperative days 0, 1 and 2.  There was also significantly less opioid consumption in the PACU and need for rescue analgesia.  This study strongly supports addition of IPACK block and ACB to a multimodal analgesic pathway.



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