Comparison of the effect of intravenous dexmedetomidine versus propofol for postoperative analgesia in ankle surgery under spinal anesthesia
Doyeon Kim, Keoungah Kim, Huigyeong Park, Jinhyoung Park, Heejoon Jeong, Jiseon Jeong and Justin Sangwook Ko
Department of Anesthesiology and Pain Medicine, Samsung Medical Center
- selective а-2 adrenoceptor agonist
- Prolong the duration of motor and sensory nerve block
- Reduce the use of analgesics within 24 hours after surgery
•The aim of this study
- Evaluate the effect of dexmedetomidine on the
analgesic effect of spinal anesthesia
- Compare opioid consumption for 24 hours after
surgery in patients undergoing ankle surgery
Materials & Methods
•This study was approved by Ethics Committee of Samsung medical center in Seoul, Korea (IRB no. 2016-11-002).
•A total of 18 patients
- ASA I, II
- Undergoing Brostrom surgery with spinal anesthesia
- Group D : dexmedetomidine 0.2 - 1 mcg/kg/h (n= 9 )
- Group P : propofol 0.5 – 3 mg/kg/h (n = 9 )
- the consumption of opioid delivered via PCA and rescue analgesics in the first 24 hours following surgery.
•Postoperative pain intensity (by visual analogue scale score) and patients’ satisfaction score were recorded
•Intravenous dexmedetomidine significantly decrease in consumption of fentanyl via IV PCA at 24 h following surgery
(group D, 133.9 ± 76.5 mcg; group P, 301.6 ± 171.4 mcg; p = 0.011).
•VAS score at 8 h and 24 h were comparable in both groups (8 h, p = 0.161; 24 h, p = 0.793).
•Patients’ satisfaction score was not statistically different (p = 0.167).
•Intravenous dexmedetomidine as a sedative agent
- Reduced the consumption of opioid in the first 24 h after Brostrom surgery with hemodynamic stability.
•It is in accordance with the previous studies which reported the synergistic effect of dexmedetomidine and local anesthetics.
•Dexmedetomidine could be a versatile sedative adjunct for ankle surgery under spinal anesthesia.