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Pain precision medicine: A polygenic risk score correlates with headache prevalence and severity
Session: MP-04a
Thurs, Nov 15, 3:45-5:15 pm
Cibolo 4

Please note, medically challenging cases are removed three months after the meeting and scientific abstracts after three years.

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Pain precision medicine: A polygenic risk score correlates with headache prevalence and severity

Daniel B Larach MD MTR MA, Anita Pandit MS, Matthew Zawistowski PhD, Daniel J Clauw MDGonçalo Abecasis PhD, Chad M Brummett MD

We constructed a polygenic risk score (PGRS) for headache from 28 loci for loosely defined headache identified by a large genome-wide association study (GWAS).

When applied to a separate cohort of 15,063 patients, the risk score was significantly associated with headache prevalence and severity.

Although the risk score correlates with headache, it is not predictive of headache.
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