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A prospective, randomized, controlled clinical trial to compare resin salve and medical honey for effectiveness on wound healing after a peripheral vascular intervention

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A prospective, randomized, controlled clinical trial to compare resin salve and medical honey for effectiveness on wound healing after a peripheral vascular intervention

 

T. Auvinen1, E. Haapakorva2, A. Sipponen3, K. Mäkinen1, J. J. Jokinen4

 

 

 

1Department of Vascular Surgery, Heart Centre, Kuopio University Hospital, Finland, 2University of Eastern Finland, 3Department of Orthopedics and Traumatology, Päijät-Häme Central Hospital, Finland 4Department of Thoracic and Vascular Surgery, Päijät-Häme Central Hospital, Finland

 

 

 

Background. The use of antimicrobial, nature-derived wound care products have rapidly increased in the Western world. Medical grade, honey-based, topical applications have been available for wound care for several years; but recently, resin-based therapeutic applications have also entered the wound care market in Europe. The treatment outcomes related to these two preparations have not been compared previously.

 

Methods. This prospective, randomized, controlled clinical trial included 40 patients that had undergone a peripheral vascular intervention, and required treatment for either a postoperatively-infected, acute surgical wound or an ischemic, chronic leg ulcer that persisted after revascularization. Patients were randomly allocated to receive either resin salve or medical honey treatment. Treatments were administered locally for up to six months.

 

Results. Nineteen (95%) patients in the resin group and 20 (100%) patients in the honey group completed the trial. At 6 months, complete wound healing was observed in 16 (84%) patients in the resin group and 11 (55%) patients in the honey group (P=.048). At 3 months [range; 69-116 days], the total number of positive bacterial cultures was reduced by 86% in the resin group and 92% in the honey group (P >.05). No hypersensitivity reaction related to either resin or honey was reported.

 

Conclusions. Resin salve and medical honey demonstrated similar clinical and antibacterial efficacy for the treatment of acutely infected surgical wounds and ischemic leg ulcers after revascularization. However, compared to medical honey, the resin salve may provide greater benefit in the late stages of wound healing; i.e., in the epithelialization phase.


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