The Nature of Beta-Glucans - and the Role in Wound Care of a Novel Bioactive Beta-Glucan Gel: Woulgan
Beta-Glucans – what are they?
Beta-glucans are natural polymers found in the cell walls of: bacteria, yeast, fungi, algae, grain and seaweed. They are foreign to the human body.
Not all beta–glucans are the same. Those derived from fungi and yeast with a (1,3) beta-linked backbone and with (1,6) beta-linked side chains are potent immune- modulators.1
Beta-glucans from microorganisms are active biological response modiers and have extensive applications in healthcare, including diabetes, metabolic syndrome, and immune system modulation.2,3,4
Beta-glucans and immune modulation
• Beta–glucans are considered pathogen associated molecular patterns (PAMPs)
• Macrophages and neutrophils have developed cell receptors which are able to recognize and bind to the PAMPs
• Macrophages are activated by beta-glucan PAMPs through several cell surface receptors, the most important being Dectin-15,6,7
• The presence of beta–glucans through PAMP recognition alerts the host of impending ‘attack’
• Macrophages surge into the area to counter microbial invasion
• Phagocytic macrophages, engulf and destroy, removing dead/senescent cells and microbes
• Macrophages support cellular proliferation, angiogenesis, and deposition of ECM through expression of growth factors PDGF, FGF, VEGF, TGF-alpha and TGF-beta and through secretion of a wide range of cytokines and chemokines
Woulgan® Bioactive Beta-Glucan Gel
A sterile, homogenous viscous gel containing soluble 1,3/1,6 Beta-Glucan (SBG), Glycerol, CMC and water in a 4 g tube.
Class III medical device that acts on phagocytic cells.
Indications – dry and low to moderately exuding wounds where there is stalled healing.
The bioactive gel is easy to apply and is available for use across specialist and generalist wound care settings including under compression or in conjunction with ofoading.
Woulgan represents a new approach in the treatment of stalled wounds
Hydrogel qualities of the gel provide a moist wound healing environment and aids autolytic debridement. The ancillary medicinal component SBG will:
• Increase wound contraction
• Activate phagocytic cells to - increase phagocytosis
- stimulate macrophages
- release signal molecules and growth factors (TNF, IL, TGF, PDGF, FGF, EGF)
• Stimulate angiogenesis
• Enhance cellular proliferation
Wound cleansing according to local practice
Debride if appropriate
Protect the wound edges, if applicable
Cover the wound surface with a thin layer of Woulgan Apply a suitable secondary dressing of choice and fixate
- Any foam dressing or wound contact layer can be used
Do not use superabsorbent dressings
Apply compression or ofoading if indicate
Apply new Woulgan at every dressing change
Woulgan Gel, containing a bioactive SBG, offers a technological advance in the management of stalled wounds. The release of signal molecules and growth factors from macrophages activates and accelerates healing in stalled wounds.