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B07
Differential Expression of MicroRNAs in Aortic Valves during LVAD-Support

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Differential Expression of MicroRNAs in Aortic Valves during LVAD-Support

Continuous unloading of the left ventricle by left ventricular assist devices (LVADs) alters blood flow dynamics, leading to the rapid development of aortic valve (AV) pathologies. We hypothesize that altered valve hemodynamics, induced by LVAD implantation, stimulate valve interstitial cells (VICs) to differentially express miRNA.

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