210 posters,  9 sessions,  10 topics,  181 authors,  155 institutions

ePostersLive® by SciGen® Technologies S.A. All rights reserved.

B04
Comparison of Fibrous Tissue Growth in Bioprosthetic Heart Valves in Chronic Sheep Models

Primary tabs

Poster Presenter
Authors
Affiliations

Rate

No votes yet

Statistics

207 reads
Pre-clinical results of RESILIA tissue reported reduced calcification and improved hemodynamics in the sheep model.4
Additionally, lower incidence of pannus and improved leaflet mobility were observed.4
Data from two sheep studies were evaluated to explore this potential benefit of RESILIA tissue.3,4
RESILIA tissue has enhanced anti-calcification properties, requires no rinsing and allows for dry storage.
Host tissue reaction is initiated by small amounts of thrombus and inflammation from the effects of surgical injury. This is primarily an issue in mitral or pulmonary position.1
Foreign body response begins with an acute inflammatory response, followed by chronic inflammation, granular tissue and foreign body-reaction-mediated encapsulation.2
Collected data from two studies using Carpentier-Edwards PERIMOUNT valves in the mitral position.
Commercially available tissue valves were used as controls to compare to the same model valve with RESILIA tissue.
Each leaflet was processed into histology slides from both studies.
Stained slides were used to identify the area of tissue growth and quantitatively analyze the area.
Stained tissue sections were scored for inflammation by a pathologist blind to the study.
In addition to low calcification, RESILIA tissue showed less host tissue overgrowth on leaflets than current commercial tissue.
Lower inflammation scores were observed in RESILIA tissue versus the control  at both time points.
Lower incidence of immune response may be related to less pannus leading to better hemodynamic outcomes and long-term durability.
 
1.  Siddiqui RF, Abraham JR and Butany J; Histopathology 55: 135-144
2.  Anderson JM. Annu. Rev. Mater. Res. Rev 2001
3.  A.B. de la Fuente et al; J. Heart Valve Dis, 24 (1): 101-109
4.  Flameng W, Hermans H, Verbeken E, Meuris B. J Thorac Cardiovasc Surg. 2015 Jan;149(1):340-5.

 

Enter Poster ID (e.gGoNextPreviousCurrent