Antiviral activity of 5-Hydroxytyrosol, a microbicidal candidate against HIV-1 transmission
José Alcamí1, Luis-Miguel Bedoya1, Patricia Obregón1, Manuela Beltrán1, Eduardo Gómez-Acebo2, David Auñón2, Laura Capa1
1Instituto de Salud Carlos III, AIDS Immunopathogenesis Unit, Majadahonda, Spain, 2Seprox Biotech SL, Madrid, Spain
5-Hydroxytyrosol (5-HT. Figure 1) is a natural compound that has previously shown biochemical activity against HIV integrase and gp41 (1,2). In this work we show that 5-HT is able to diminish viral replication without toxic effects in vitro.